Donor dendritic cell–derived exosomes promote allograft-targeting immune response

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Donor dendritic cell-derived exosomes promote allograft-targeting immune response.

The immune response against transplanted allografts is one of the most potent reactions mounted by the immune system. The acute rejection response has been attributed to donor dendritic cells (DCs), which migrate to recipient lymphoid tissues and directly activate alloreactive T cells against donor MHC molecules. Here, using a murine heart transplant model, we determined that only a small numbe...

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fibroblast and t cells conditioned media induce maturation dendritic cell and promote t helper immune response

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Erratum: Donor-derived exosomes induce specific regulatory T cells to suppress immune inflammation in the allograft heart

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 2016

ISSN: 0021-9738,1558-8238

DOI: 10.1172/jci84577